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KMID : 1007420100080020126
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Mood and Emotion
2010 Volume.8 No. 2 p.126 ~ p.132
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The Association of Serum Alanine Aminotransferase and Metabolic Syndrome in Patients with Bipolar Disorder
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Yoon Hye-Ri
Lee Hyun-Jeong
Lee Nam-Young
Yu Han-Young
Kim Yong-Sik
Ahn Yong-Min
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Abstract
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Background and Objectives：We aimed to investigate the association between alanine aminotransferase (ALT)level and metabolic syndrome (MetS) in patients with bipolar disorder.
Materials and Method：A total of 151bipolar patients who visited the psychiatric clinic in Seoul National University Hospital and have all measures for the diagnosis of MetS for 2 years were studied. Participants with normal ALT were divided 3 groups according to the tertiles of ALT levels for each gender.
Results：Patients with high ALT level (ALT>40 IU/L, n=21) showed higher level of body mass index, blood pressures, fasting glucose, triglyceride, and waist circumference (WC) and higher chance of MetS, compared to those with normal ALT level (n=130). In overall patients and women, ALT level increased accordingly, as the number of MetS components increased (both p<0.001). Normal ALT subjects were divided into 3 groups according to tertiles of ALT levels. High normal ALT Group (19≤ALT≤40 IU/L)was more likely to have MetS (odds ratio [OR] 8.72, p=0.001) than low normal ALT group (ALT<13 IU/L). After adjustment for age, OR was 5.77 (p=0.012). Similar results were maintained in each gender.
Conclusion：Serum ALT level, even in the normal range, was closely associated with MetS in bipolar patients.
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KEYWORD
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Bipolar disorder, Metabolic syndrome, Alanine aminotransferase
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